Kidney Injury Molecule-1 (KIM-1): Biomarker of Tubular Injury and Predictor of Kidney Disease Progression
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References
1. Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 1985;28(5):830–838. doi:10.1038/ki.1985.205
2. Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis. 1992;20(1):1–17. doi:10.1016/s0272-6386(12)80312-x
3. Lousa I, Reis F, Beirão I, Alves R, Belo L, Santos-Silva A. New potential biomarkers for chronic kidney disease management—A review of the literature. Int J Mol Sci. 2020;22(1):43. doi:10.3390/ijms22010043
4. Shaker AM, Rakha NK, El-Shehaby AMR. The significance of fibroblast growth factor-2 and kidney injury molecule-1 as biomarker of interstitial renal fibrosis in glomerulonephritis. Egypt J Intern Med. 2022;34:28. doi:10.1186/s43162-022-00112-0
5. Song J, Yu J, Prayogo GW, Cao W, Wu Y, Jia Z, et al. Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology. Am J Transl Res. 2019;11(3):1219–29.
6. Su Y, Yang X, Cheng WW, Shang XM, H-L W, Shen HC. Kidney injury molecule 1 in the early detection of acute kidney injury—a systematic review and meta-analysis. Front Med. 2025;12:1574945. doi:10.3389/fmed.2025.1574945
7. Zhang PL, Liu ML. From acute tubular injury to tubular repair and chronic kidney diseases – KIM-1 as a promising biomarker for predicting renal tubular pathology. Curr Res Physiol. 2025;8:100152. doi:10.1016/j.crphys.2025.100152
8. Sari PA, Priyono D, Harun H, Viotra D, Najirman, Fauzar, et al. Diagnostic value of urinary kidney injury molecule-1 in diagnosis of sepsis associated acute kidney injury. InaKidney. 2026;3(2):210–6. doi:10.32867/inakidney.v3i2.263
9. Ostermann M, Basu RK, Mehta RL. Acute kidney injury. Intensive Care Med. 2023;49(2):219–22. doi:10.1007/s00134-022-06946-0
10. Xie Y, Huang P, Zhang J, Tian R, Jin W, H X. Biomarkers for the diagnosis of sepsis-associated acute kidney injury: systematic review and meta-analysis. Ann Palliat Med. 2021;10(4):4159–73. doi:10.21037/apm-20-1855
11. Ko GJ, Grigoryev DN, Linfert D, Jang HR, Watkins T, Cheadle C, et al. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Am J Physiol Ren Physiol. 2010;298(6):F1472-83. doi:10.1152/ajprenal.00619.2009
12. Huang R, Fu P, Ma L. Kidney fibrosis: from mechanisms to therapeutic medicines. Signal Transduct Target Ther. 2023;8(1):129. doi:10.1038/s41392-023-01379-7
13. Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, et al. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type 1 diabetes. J Am Soc Nephrol. 2014;25(10):2177–2186. doi:10.1681/asn.2013070758
2. Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis. 1992;20(1):1–17. doi:10.1016/s0272-6386(12)80312-x
3. Lousa I, Reis F, Beirão I, Alves R, Belo L, Santos-Silva A. New potential biomarkers for chronic kidney disease management—A review of the literature. Int J Mol Sci. 2020;22(1):43. doi:10.3390/ijms22010043
4. Shaker AM, Rakha NK, El-Shehaby AMR. The significance of fibroblast growth factor-2 and kidney injury molecule-1 as biomarker of interstitial renal fibrosis in glomerulonephritis. Egypt J Intern Med. 2022;34:28. doi:10.1186/s43162-022-00112-0
5. Song J, Yu J, Prayogo GW, Cao W, Wu Y, Jia Z, et al. Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology. Am J Transl Res. 2019;11(3):1219–29.
6. Su Y, Yang X, Cheng WW, Shang XM, H-L W, Shen HC. Kidney injury molecule 1 in the early detection of acute kidney injury—a systematic review and meta-analysis. Front Med. 2025;12:1574945. doi:10.3389/fmed.2025.1574945
7. Zhang PL, Liu ML. From acute tubular injury to tubular repair and chronic kidney diseases – KIM-1 as a promising biomarker for predicting renal tubular pathology. Curr Res Physiol. 2025;8:100152. doi:10.1016/j.crphys.2025.100152
8. Sari PA, Priyono D, Harun H, Viotra D, Najirman, Fauzar, et al. Diagnostic value of urinary kidney injury molecule-1 in diagnosis of sepsis associated acute kidney injury. InaKidney. 2026;3(2):210–6. doi:10.32867/inakidney.v3i2.263
9. Ostermann M, Basu RK, Mehta RL. Acute kidney injury. Intensive Care Med. 2023;49(2):219–22. doi:10.1007/s00134-022-06946-0
10. Xie Y, Huang P, Zhang J, Tian R, Jin W, H X. Biomarkers for the diagnosis of sepsis-associated acute kidney injury: systematic review and meta-analysis. Ann Palliat Med. 2021;10(4):4159–73. doi:10.21037/apm-20-1855
11. Ko GJ, Grigoryev DN, Linfert D, Jang HR, Watkins T, Cheadle C, et al. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition. Am J Physiol Ren Physiol. 2010;298(6):F1472-83. doi:10.1152/ajprenal.00619.2009
12. Huang R, Fu P, Ma L. Kidney fibrosis: from mechanisms to therapeutic medicines. Signal Transduct Target Ther. 2023;8(1):129. doi:10.1038/s41392-023-01379-7
13. Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C, Ravisankar A, et al. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type 1 diabetes. J Am Soc Nephrol. 2014;25(10):2177–2186. doi:10.1681/asn.2013070758
Published
2026-08-24
How to Cite
1.
Samsu N. Kidney Injury Molecule-1 (KIM-1): Biomarker of Tubular Injury and Predictor of Kidney Disease Progression. inakidney [Internet]. 24Aug.2026 [cited 25Aug.2026];3(2):207-9. Available from: https://inakidneyhypertension.co.id/index.php/inakidney/article/view/280
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