Patterns of Kidney Diseases in Native Biopsies: A Single-Center Experience
Abstract
Background: Kidney biopsy is the definitive diagnostic method for kidney disease, providing essential histopathological information for prognosis and treatment. However, in Indonesia, comprehensive data on kidney biopsy patterns remain limited, making it difficult to assess disease prevalence and epidemiological trends.
Objective: To analyze the epidemiology of biopsy-confirmed kidney diseases in a single-center cohort and evaluate the distribution of clinical and histopathological diagnoses.
Methods: A retrospective descriptive analysis was performed on patients who underwent a kidney biopsy at Siloam Hospital Kebon Jeruk between January 2021 and August 2024. Data on demographics, clinical manifestations, biopsy indications, histopathological findings, and immunofluorescence results were analyzed using descriptive statistics.
Results: A total of 45 kidney biopsies were conducted, resulting in a biopsy rate of 5.24 per 1,000 individuals, higher among young adults (15–44 years). The median patient age was 43 years, with a nearly equal male-to-female ratio. Nephrotic syndrome was the leading clinical presentation (35.9%), followed by nephritic syndrome (33.3%). Hematuria and proteinuria (35.6%) were the most frequent biopsy indications. Glomerular diseases represented as majority of histopathological diagnoses, with focal segmental glomerulosclerosis (FSGS) being the most common finding (37.8%), followed by lupus nephritis and IgA nephropathy. A rare case of monoclonal gammopathy of renal significance was also identified.
Conclusion: This study provided insight into biopsy-confirmed kidney disease patterns in Indonesia. The predominance of glomerular diseases, particularly FSGS, aligns with global trends. The low biopsy rate underscores the need for expanded nephrology services and further multicenter studies to develop a comprehensive national kidney disease registry.
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References
Francis A, Harhay MN, Ong ACM, Tummalapalli SL, Ortiz A, Fogo AB, et al. Chronic kidney disease and the global public health agenda: An international consensus. Nat Rev Nephrol. 2024;20(7):473–85. doi:10.1038/s41581-024-00820-6
Hogan JJ, Mocanu M, Berns JS. The native kidney biopsy: Update and evidence for best practice. Clin J Am Soc Nephrol. 2016;11(2):354–6. doi:10.2215/cjn.05750515
Afiatin. 13th Annual Report of Indonesian Renal Registry 2020. 2023.
RI KK. Laporan Nasional Riskesdas 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2019.
Paz JC. Genitourinary System. In: Paz JC, editor. Acute Care Handbook for Physical Therapists. Fourth. Elsevier; 2014. p. 225–42. doi:10.1016/b978-1-4557-2896-1.00009-3
International Society of Nephrology. KDIGO 2024 Clinical Practice Guidelines for the Evaluation and Management of Chronic Kidney Disease. Kidney Dis Improv Glob Outcome. 2024;105(4S):A1–A1. doi:10.1016/s0085-2538(24)00110-8
Fiorentino M, Bolignano D, Tesar V, Pisano A, Van Biesen W, D’Arrigo G, et al. Renal biopsy in 2015 - From epidemiology to evidence-based indications. Am J Nephrol. 2016;43(1):1–19. doi:10.1159/000444026
Jumlah Penduduk Hasil Proyeksi (Jiwa), 2018-2019 [Internet]. Badan Pusat Statistik Kota Jakarta Barat. 2020. Available from: https://jakbarkota.bps.go.id/id/statistics-table/2/MjkjMg==/jumlah-penduduk-hasil-proyeksi.html
Laurens W, Deleersnijder D, Dendooven A, Lerut E, De Vriese AS, Dejagere T, et al. Epidemiology of native kidney disease in Flanders: Results from the FCGG kidney biopsy registry. Clin Kidney J. 2022;15(7):1361–72. doi:10.1093/ckj/sfac033
Li H, Yu X, Lan P, Wang Z, Yang S, Feng J, et al. Spectrum of biopsy-proven kidney diseases in northwest China: a review of 30 years of experiences. Int Urol Nephrol. 2022;54(10):2609–16. doi:10.1007/s11255-022-03168-7
Bobart SA, Portalatin G, Sawaf H, Shettigar S, Carrion-Rodriguez A, Liang H, et al. The Cleveland Clinic Kidney Biopsy Epidemiological Project. Kidney 360. 2022;3(12):2077–85. doi:10.34067/kid.0005882022
Y YS, C RA, M TK, L LM, C YY, S WH, et al. 6 th Report of The Malaysian Registry of Renal Biopsy [Internet]. Kuala Lumpur; 2019. Available from: https://www.macr.org.my/emrrb
Shakeel S, Rashid R, Mubarak M. Renal Data from the Asia-Africa Biopsy-Proven Renal Diseases in the Elderly: A Developing Country Perspective. Saudi J Kidney Dis Transpl. 2022;33(2):313–22. doi:10.4103/1319-2442.379030
Rosenberg AZ, Kopp JB. Focal Segmental Glomerulosclerosis. Clin J Am Soc Nephrol. 2017;12(3):502–17. doi:10.2215/cjn.12071018
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