Dialysis Vintage, Vitamin D, and Bone Mineral Density of CKD Patients on Chronic Hemodialysis
Background: Bone mineral disorders in chronic kidney disease (CKD-MBD) is one of the complications that occurs due to systemic disorders of minerals and bones in chronic kidney disease (CKD). This syndrome is one or a combination of laboratory abnormalities (phosphate, parathyroid hormone, and vitamin D), bone disorders (turnover, mineralization, volume, linear growth, and strength), and/or vascular calcification or other soft tissue. It is associated with high mortality and morbidity in CKD patients. To determine the relationship of vitamin D levels and bone mineral density (BMD) examination with the hemodialysis vintage in CKD patients undergoing hemodialysis at RSUD Dr. ZainoelAbidin.
Methods: This study is a cross-sectional study held in Zainoel Abidin Hospital, Banda Aceh, Indonesia, from January until May 2017. We include all patients who received twice-weekly hemodialysis for at least 3 months. Patients who received corticosteroids in the past 2 weeks, pregnancy, suffering from endocrine disorders, malignancy, menopausal women, autoimmune diseases, and thalassemia were excluded. Laboratory examination and Bone Densitometry were performed before a single hemodialysis session. Data were analyzed using the Spearman Rank Correlation test.
Results: Thirty patients were analyzed from 196 hemodialysis patients. The proportion of patients that have vitamin D insufficiency was 56.6%. The proportion of patients that have with normal vitamin D was 43.3%. The proportion of patients that have osteoporosis was 30% and 56.6% were osteopenia based on bone densitometry examination. The magnitude of the Spearman Rank Correlation coefficient between vitamin D levels and the duration of hemodialysis in CKD patients is -0.552 with a p-value 0.002. The magnitude of the Spearman Rank Correlation coefficient between BMD and hemodialysis time in CKD patients is -0,397 with a p-value of less than 0.030.
Conclusion: There was a correlation between dialysis vintage with vitamin D levels and bone densitometry.
Copyright (c) 2020 Maimun Syukri, Desi Salwani, Khairunnisa Khairunnisa, Abdullah Abdullah
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