Correlation between Urinary Cyclophilin A and Urinary Albumin Levels on Diabetic Kidney Disease

  • Harnavi Harun Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Andalas - M. Djamil General Hospital, Padang, Indonesia
  • Rangga Lunesia Department of Internal Medicine, Faculty of Medicine Universitas Andalas - M. Djamil General Hospital, Padang, Indonesia
  • Syaiful Azmi Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Andalas - M. Djamil General Hospital, Padang, Indonesia
Keywords: urinary cyclophilin a, urinary albumin, diabetic kidney disease

Abstract

Introduction: Diabetic kidney disease (DKD) is a complication of diabetes mellitus characterized by albuminuria persisting within 3 to 6 months, the earliest clinical evidence is microalbuminuria (30-299 mg/24hours or 20-199 ug/i). Cyclophilin A (Cyp A) is an 18 k-Da 165-amino acid long cytosolic protein also known as peptidylprolyl isomerase A. In DN, hyperglycemia will cause Cyp A secretion by human kidney-2 (HK-2) cells from PTEC and mesangial-13 cells (MES-13) and causes kidney damage.

Material and Methods: This study was an analytic observational, cross sectional study conducted at the clinic and inpatient internal medicine installation at dr. M. Djamil General Hospital Padang  for 6 months. Samples were selected by consecutive sampling, as many as 60 people with post prandial blood glucose > 180 mg/dl and urinary albumin > 30 mg/24 hours and met the inclusion and exclusion criteria. The samples were examined for urinary Cyp A and albumin levels.

Results: The mean level of urinary Cyp A in patients with DKD is 4.96 (2.03) ng/ml. Median urinary albumin levels in DKD patients is 287.89 (30.79-394.57) mg/24 hours. Correlation analysis between urinary Cyp A and albumin levels showed a significant (p < 0.05) with a positive and strong correlation (r = 0.776) in DKD patients.

Conclusion: There was an increase of urinary Cyp A and urinary albumin levels, with a positive and strong correlation between them in DKD patients.

Keywords: Urinary Cyclophilin A, urinary albumin, diabetic kidney disease

 

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Published
2019-07-31
How to Cite
1.
Harun H, Lunesia R, Azmi S. Correlation between Urinary Cyclophilin A and Urinary Albumin Levels on Diabetic Kidney Disease. inakidney [Internet]. 31Jul.2019 [cited 22Feb.2024];2(2):10-6. Available from: http://inakidneyhypertension.co.id/index.php/inakidney/article/view/29
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Original Articles