Risk Factors for New-Onset Diabetes After Transpant in Kidney Transplant Recipients

  • Dana Pramudya Universitas Airlangga
  • Aditiawardana Aditiawardana Universitas Airlangga
  • Artaria Tjempakasari Universitas Airlangga
  • Chandra Irwanadi Universitas Airlangga
  • Nunuk Mardiana Universitas Airlangga
  • Pranawa Pranawa Universitas Airlangga
  • Widodo Widodo Universitas Airlangga
Keywords: NODAT, kidney transplant, risk factor

Abstract

Background New-onset diabetes after transplant (NODAT) is one of the metabolic complications of kidney transplant surgery. The incident of NODAT varies highly, from 5% up to 53%. Some factors increase the risk for NODAT, such as age, gender, immunosuppressant drugs, among others. The progressivity of NODAT leads to increased cardiovascular risks, making the identification of risk factors crucial.

Method Medical records of 56 patients who have undergone kidney transplant throughout 1998 - 2015 were evaluated. Data obtained from the records include age, gender, history of hypertension, dyslipidemia, the use of calcineurin inhibitors (CNI), and familial history of diabetes. Bivariate analysis with crosstabs (for nominal data) was used to analyze the data, with a threshold of p < 0.25 and followed up with multivariate analysis using logistic regression.

Result The mean age of subjects was 53.85±12.92 years, with 80.4% of the subjects were male. Pre-transplant hypertension was 46.4%. The CNI used were tacrolimus in 46.4% and cyclosporine in 53.6% of patients. Around 25% of patients have a familial history of diabetes and the mean triglyceride level was 165.83±77.5 mg/dl. NODAT occurred in 18 patients and the majority of occurrence happened in the first year post-transplant. Bivariate analysis shows no significant risk factors, however clinically significant risk factors were gender (male), the CNI drug used (tacrolimus), and familial history of diabetes. Further multivariate analysis showed OR for gender (male) with OR 6.532 (0.735- 58.051), age with OR 5.249 (0.658-41.853)}, and the use of tacrolimus with OR 3.217 (0.895-11.571).

Conclusion In this study, the clinically significant risk factors for NODAT were male gender, age, and the use of tacrolimus. However, these risk factors did not show statistical significance. Further study with bigger sample size is needed.

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Author Biographies

Dana Pramudya, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Aditiawardana Aditiawardana, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Artaria Tjempakasari, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Chandra Irwanadi, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Nunuk Mardiana, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Pranawa Pranawa, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Widodo Widodo, Universitas Airlangga

Division of Nephrology, Department of Internal Medicine, Dr. Soetomo General Hospital – Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia

Published
2019-04-01
How to Cite
1.
Pramudya D, Aditiawardana A, Tjempakasari A, Irwanadi C, Mardiana N, Pranawa P, Widodo W. Risk Factors for New-Onset Diabetes After Transpant in Kidney Transplant Recipients. inakidney [Internet]. 1Apr.2019 [cited 31Mar.2020];2(1):29 -32. Available from: http://inakidneyhypertension.co.id/index.php/inakidney/article/view/25
Section
Original Articles